The travel to California this week to face the on "Sunday Night Football." Doug Pederson's squad is still searching for its first win, as the Eagles tied the last week, 23-23. As for the 49ers, they pulled out a win against the in dominant fashion despite mi sing several key starters. While they get tight end and wide receiver Deebo Samuel back this week, they will be mi sing quarterback , running back , tight end , defensive end , cornerback , linebacker and cornerback .A starting quarterback being ruled out for a primetime matchup is always worrisome, but completed Clelin Ferrell Jersey 69 percent of his pa ses for 343 yards and a touchdown last week against the Giants. He appears to be a decent replacement -- especially against a team that has given up a total of 87 points through three games.Below, we will get you caught Carl Nassib Jersey up on the most intriguing betting angles to get you locked in before kickoff. All odds are via William Hill Sportsbook.Date:Sunday, October 4|Time:8:20 p.m. ETLocation:Levi's Stadium (Santa Clara, California)TV: NBC|Stream:fuboTV ( )Follow: This line has seen some movement, as it reopened at 49ers -6.5 on Sunday night, dropped to 49ers -6 on Monday, but climbed to 49ers -7 on Saturday. By Sunday, it was all the way up to 49ers -9 Charles Woodson Jersey .The pick: Eagles +9.Since I have been burned by the Eagles already twice this year, I'm required to inform you all that this is much more of a lean than a lock. I have the 49ers winning this game, but I question if they will cover the spread. agree with me on this pick, however.The total reopened at 43 on Sunday night, but has steadily increased as the week has gone on. The pick: Over 45.5. is leaning over on the total. In fact, it's calling for 46 total points. While the Eagles average just 19.7 points per game, the 49ers average 29. total Richard Seymour Jersey rushing yards: Over 63.5 (-115).Sanders has rushed for 95 yards in each of the two games he has played in this season, so I'll probably take the Over here. San Francisco has allowed an average of 116.7 rushing yards per game so far this year, and Sanders is undoubtedly Philadelphia's lead back. total receptions: Over 4.5 (+110). , and are out due to injury and J.J. Arcega-Whiteside is doubtful, so Ward will be the go-to receiver again on Sunday. Last week, Willie Snead IV Jersey he caught eight of 11 targets for 72 yards and a touchdown. Ward also caught five pa ses in the season opener on Washington, so I'm banking on him catching at least five balls this Sunday. Nick Mullens total pa sing completions: Over 22.5 (-120).Mullens completed 25 of 36 pa ses against the Giants in what was a blowout win, and I think he is going to have to throw more this week. I may bet the Over on his attempts as well (Over 32.5, -125).