Yes, Can Metoprolol Cause ED, a beta-blocker commonly used to treat high blood pressure and certain heart conditions. Beta-blockers can affect blood circulation and the relaxation of blood vessels, which are important for achieving and maintaining an erection. Metoprolol may influence hormone levels, including testosterone, which plays a key role in libido and sexual performance. Not everyone who takes metoprolol will experience ED; individual responses to medications can vary.