Avana is a medication used to treat erectile dysfunction (ED). Its active ingredient is avanafil, which is a phosphodiesterase type 5 (PDE5) inhibitor. The active ingredient in Avana is avanafil, which helps treat erectile dysfunction by increasing blood flow to the penis. By blocking PDE5, avanafil helps maintain higher levels of cGMP, leading to relaxation of smooth muscles and increased blood flow, which facilitates achieving and maintaining an erection in response to sexual stimulation. It is usually taken orally with water, about 15-30 minutes before sexual activity. It should not be taken more than once a day.